A Swine Model of Severe Propranolol Toxicity Permitting Direct Measurement of Brain Tissue Oxygenation.

Benjamin S OrozcoKristin M EngebretsenJoel S HolgerSamuel J Stellpflug

Published in: Journal of medical toxicology : official journal of the American College of Medical Toxicology (2019)

We report a pilot study swine model of propranolol toxicity with hypotension despite HDI, in which physiologic measures including PbrO2 are achieved. Our toxicity model can be used in the future, and the hemodynamic and brain monitoring model may prove important for subsequent research in various contexts.

Keyphrases

oxidative stress
white matter
brain injury
current status