Glutamine promotes the proliferation of epithelial cells via mTOR/S6 pathway in oral lichen planus.

Jiaqi HuZihang LingWei LiZhangci SuJingyi LuQi ZengBin ChengXiaoan Tao

Published in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2022)

Gln metabolism is essential to maintain the balance of proliferation and apoptosis in oral epithelial cells, and inhibition of Gln metabolism may have a beneficial effect on OLP treatment.

Keyphrases

signaling pathway
oxidative stress
endoplasmic reticulum stress
cell proliferation
cell cycle arrest
combination therapy