IDH-mutant brainstem gliomas in adolescent and young adult patients: Report of three cases and review of the literature.

Ellen K ChangMatthew A Smith-CohnBenita TamraziJianling JiMark KriegerMatthias HoldhoffCharles G EberhartAshley S MargolJennifer A Cotter

Published in: Brain pathology (Zurich, Switzerland) (2021)

Isocitrate dehydrogenase (IDH) mutations are rare in pediatric and adolescent gliomas. We recently identified three adolescent/young adult (AYA) patients with IDH-mutant low grade gliomas of the brainstem with several key clinicopathologic and molecular features in common. We discuss these three cases and review the current literature.

Keyphrases

low grade
high grade
young adults
wild type
childhood cancer
mental health
end stage renal disease
ejection fraction
newly diagnosed
systematic review
prognostic factors
patient reported outcomes