Diazepam induced sleep spindle increase correlates with cognitive recovery in a child with epileptic encephalopathy.

S M StoyellB S BaxterJ McLarenH KwonD M ChinappenL OstrowskiL ZhuJ A GriecoM A KramerA K MorganB C EmertonD S ManoachCatherine J Chu

Published in: BMC neurology (2021)

Epileptic encephalopathies are challenging electroclinical syndromes characterized by combined seizures and a deceleration or regression in cognitive skills over childhood. This report identifies thalamocortical circuit dysfunction in a case of epileptic encephalopathy and motivates future investigations of sleep spindles as a biomarker of cognitive function and a potential therapeutic target in this challenging disease.

Keyphrases

early onset
sleep quality
physical activity
oxidative stress
diabetic rats
current status
drug induced
depressive symptoms
risk assessment