Adipose tissue mitochondrial dysfunction in human obesity is linked to a specific DNA methylation signature in adipose-derived stem cells.

Miriam EjarqueVictoria Ceperuelo-MallafréCarolina SerenaElsa Maymo-MasipXevi DuranAngels Díaz-RamosMonica Millan-ScheidingYaiza Núñez-ÁlvarezCatalina Núñez-RoaPau GamaPablo M Garcia-RovesMiquel A PeinadoJeffrey M GimbleAntonio ZorzanoJoan VendrellSonia Fernández-Veledo

Published in: International journal of obesity (2005) (2018)

We identified a DNA methylation signature in adipocyte precursors associated with obesity, which has a significant impact on the metabolic phenotype of mature adipocytes.

Keyphrases

adipose tissue
insulin resistance
dna methylation
high fat diet induced
metabolic syndrome
high fat diet
genome wide
weight loss
gene expression
type diabetes
endothelial cells
weight gain
skeletal muscle
wound healing
physical activity