Electric field stimulation boosts neuronal differentiation of neural stem cells for spinal cord injury treatment via PI3K/Akt/GSK-3β/β-catenin activation.

Qian LiuVsevolod TelezhkinWenkai JiangYu GuYan WangWei HongWeiming TianPolina YarovaGaofeng ZhangSimon Ming-Yuen LeePeng ZhangMin ZhaoNicholas D AllenEmilio HirschJosef PenningerBing Song

Published in: Cell & bioscience (2023)

In conclusion, we demonstrated physiological EF stimulation as an efficient method to boost the neuronal differentiation of NSCs via the PI3K/Akt/GSK-3β/β-catenin activation. Pre-treatment with the EF stimulation induction before NSCs transplantation would notably improve the therapeutic outcome for neurogenesis and neurofunction recovery of SCI.

Keyphrases

pi k akt
spinal cord injury
signaling pathway
cell proliferation
neural stem cells
epithelial mesenchymal transition
cell cycle arrest
stem cells
bone marrow
brain injury
mesenchymal stem cells
blood brain barrier