Mendelian randomisation study of the effects of known and putative risk factors on pancreatic cancer.

Ye LuManuel GentiluomoJusto Lorenzo-BermejoLuca MorelliOfure ObazeeDaniele CampaFederico Canzian

Published in: Journal of medical genetics (2020)

We found strong evidence that BMI is causally associated with PDAC risk, providing support that obesity management may be a potential prevention strategy for reducing pancreatic cancer risk while fasting insulin and type 2 diabetes showed a suggestive association that should be further investigated.

Keyphrases

type diabetes
insulin resistance
risk factors
glycemic control
metabolic syndrome
weight gain
weight loss
cardiovascular disease
blood glucose
body mass index
skeletal muscle
adipose tissue
blood pressure
high fat diet induced
atomic force microscopy
high resolution
mass spectrometry
single molecule