Genomic and clinical characterisation of multidrug-resistant carbapenemase-producing ST231 and ST16 Klebsiella pneumoniae isolates colonising patients at Siriraj hospital, Bangkok, Thailand from 2015 to 2017.
Adhiratha BoonyasiriElita JauneikaiteLauren M BrinkacChris GrecoKanokorn LerdlamyongTeerawit TangkoskulKevin NguyenVisanu ThamlikitkulDerrick E FoutsPublished in: BMC infectious diseases (2021)
This study has revealed the genomic features of colonising CPE isolates, focusing on antimicrobial resistance and virulence determinants. This type of multi-layered analysis can be further exploited in Thailand and elsewhere to modify the regimes used for empirical antibiotic treatment and improve the management strategies for CPE infections in hospitalised patients.
Keyphrases
- klebsiella pneumoniae
- multidrug resistant
- antimicrobial resistance
- escherichia coli
- gram negative
- acinetobacter baumannii
- drug resistant
- end stage renal disease
- ejection fraction
- pseudomonas aeruginosa
- peritoneal dialysis
- single cell
- copy number
- prognostic factors
- gene expression
- emergency department
- biofilm formation
- gold nanoparticles
- reduced graphene oxide
- acute care
- patient reported