The short-term effects of sacubitril/valsartan therapy on myocardial oxygen consumption and energetic efficiency of cardiac work in heart failure with reduced ejection fraction. A randomized controlled study.

We found no differences in the energetic efficiency of cardiac work between ARNI and valsartan-only groups in HFrEF patients. However, ARNI appears to have hemodynamic and cardiac mechanical effects over valsartan in patients with HF. (EudraCT 2017-002113-64) This article is protected by copyright. All rights reserved.