Cyclosporine A induces cardiac remodeling through TGF-β/Smad3/miR-29 signaling pathway and alters gene expression of miR-30b-5p/CaMKIIδ isoforms pathways: alleviating effects of moderate exercise.
Khatereh NourmohammadiAbolfazl BayramiRoya NaderiAlireza ShirpoorPublished in: Molecular biology reports (2023)
TGF-β-Smad3-miR-29 and CaMKIIδ isoforms may mainly contribute to the progression of heart fibrosis and hypertrophy due to CsA exposure, providing new insight into the pathogenesis and treatment of CsA-induced side effects on the heart tissue.
Keyphrases
- transforming growth factor
- epithelial mesenchymal transition
- gene expression
- cell proliferation
- long non coding rna
- signaling pathway
- high intensity
- heart failure
- long noncoding rna
- dna methylation
- high glucose
- left ventricular
- physical activity
- diabetic rats
- atrial fibrillation
- resistance training
- induced apoptosis
- oxidative stress
- liver fibrosis
- body composition