CHD1 Promotes Sensitivity to Aurora Kinase Inhibitors by Suppressing Interaction of AURKA with Its Coactivator TPX2.
Haoyan LiYin WangKevin LinVaradha Balaji VenkadakrishnanMartin K BakhtWei ShiChenling MengJie ZhangKaitlyn TrembleXin LiangJian H SongXu FengVivien VanPingna DengJared K BurksAna M AparicioKhandan KeyomarsiJunjie ChenYue LuHimisha BeltranDi ZhaoPublished in: Cancer research (2022)
CHD1 plays a critical role in controlling AURKA activation and promoting Aurora kinase inhibitor sensitivity, providing a potential clinical biomarker to guide cancer treatment.
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