Prediagnostic plasma metabolomics and the risk of amyotrophic lateral sclerosis.
Kjetil BjornevikZhongli ZhangÉilis J O'ReillyJames D BerryAndrew T ChanAmy DeikSarah JeanfavreIkuko KatoRachel S KellyLaurence N KolonelLiming LiangLoic Le MarchandMarjorie L McCulloughSabrina PaganoniKerry A PierceMichael A SchwarzschildAladdin H ShadyabJean Wactawski-WendeDong D WangYing WangJoAnn E MansonAlberto AscherioPublished in: Neurology (2019)
Although the metabolomic profile in blood samples collected years before ALS diagnosis did not reliably separate presymptomatic ALS cases from controls, our results suggest that ALS is preceded by a broad, but poorly defined, metabolic dysregulation years before the disease onset.