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Mutations in the HBV PreS/S gene related to hepatocellular carcinoma in Vietnamese chronic HBV-infected patients.

Huong Thi Cam NguyenNguyen Quang TrungBac An LuongDuong Bich TramHoang Anh VuHoang Huu BuiHoa Pham Thi Le
Published in: PloS one (2022)
We detected 61% amino acid changes on PreS/S regions in Vietnamese CHB patients. One point-mutation at amino acid 4 on PreS1 gene and 4 point-mutations at amino acids 47, 120, 174, and 203 on S gene were associated with HCC. Further investigations are recommended to further clarify the relationship and interaction between mutations in HBV genome and HCC progression.
Keyphrases
  • amino acid
  • hepatitis b virus
  • genome wide
  • copy number
  • end stage renal disease
  • liver failure
  • genome wide identification
  • ejection fraction
  • newly diagnosed
  • chronic kidney disease
  • peritoneal dialysis
  • dna methylation