DNA methylation of the BRD2 promoter is associated with juvenile myoclonic epilepsy in Caucasians.

Shilpa PathakJames MillerEmily C MorrisWilliam C L StewartDavid A Greenberg

Published in: Epilepsia (2018)

BRD2 promoter methylation in JME, and the lack of methylation in unaffected relatives, in non-JME GGE patients, and in non-Caucasian JME, demonstrate that methylation specificity is a possible seizure susceptibility motif in JME risk and suggests JME therapeutics targeting BRD2.

Keyphrases

dna methylation
genome wide
gene expression
end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
transcription factor
small molecule
prognostic factors
patient reported outcomes
patient reported