Clinical impact of intratumoral HER2 heterogeneity on trastuzumab efficacy in patients with HER2-positive gastric cancer.

Takeru WakatsukiNoriko YamamotoTakeshi SanoKeisho ChinHiroshi KawachiDaisuke TakahariMariko OguraTakashi IchimuraIzuma NakayamaHiroki OsumiTomohiro MatsushimaMitsukuni SuenagaEiji ShinozakiNaoki HikiYuichi IshikawaKensei Yamaguchi

Published in: Journal of gastroenterology (2018)

Intratumoral HER2 heterogeneity may have robust clinical impact on trastuzumab efficacy in patients with HER2-positive gastric cancer. These findings should be validated by larger independent cohorts and further molecular correlative analyses are warranted.

Keyphrases

epidermal growth factor receptor
single cell
metastatic breast cancer
single molecule
tyrosine kinase