Anakinra, an interleukin-1 receptor antagonist, increases the morphine analgesic effect and decreases morphine tolerance development by modulating oxidative stress and endoplasmic reticulum stress in rats

Published in: Turkish journal of medical sciences (2020)

Anakinra has antinociceptive properties, and it increases the analgesic effect of morphine and also prevents tolerance development. These effects probably occur by the modulation of oxidative stress and ER-stress pathways.

Keyphrases

endoplasmic reticulum stress
oxidative stress
induced apoptosis
anti inflammatory
dna damage
neuropathic pain
ischemia reperfusion injury
spinal cord
mouse model
heat shock