Taeanamides A and B, Nonribosomal Lipo-Decapeptides Isolated from an Intertidal-Mudflat-Derived Streptomyces sp.
Jinsheng CuiEunji KimDong Hyun MoonTae Ho KimIlnam KangYeonjung LimDaniel ShinSunghoon HwangYoung Eun DuMyoung Chong SongMunhyung BaeJang-Cheon ChoJichan JangSang-Kook LeeYeo Joon YoonDong-Chan OhPublished in: Marine drugs (2022)
Two new lipo-decapeptides, namely taeanamides A and B ( 1 and 2 ), were discovered from the Gram-positive bacterium Streptomyces sp. AMD43, which was isolated from a mudflat sample from Anmyeondo, Korea. The exact molecular masses of 1 and 2 were revealed by high-resolution mass spectrometry, and the planar structures of 1 and 2 were elucidated using NMR spectroscopy. The absolute configurations of 1 and 2 were determined using a combined analysis of 1 H- 1 H coupling constants and ROESY correlations, the advanced Marfey's method, and bioinformatics. The putative nonribosomal peptide synthetase pathway for the taeanamides was identified by analyzing the full genome sequence data of Streptomyces sp. AMD43. We also found that taeanamide A exhibited mild anti-tuberculosis bioactivity, whereas taeanamide B showed significant bioactivity against several cancer cell lines.
Keyphrases
- high resolution mass spectrometry
- liquid chromatography
- papillary thyroid
- mycobacterium tuberculosis
- age related macular degeneration
- gram negative
- hiv aids
- emergency department
- squamous cell carcinoma
- mass spectrometry
- computed tomography
- contrast enhanced
- gene expression
- pulmonary tuberculosis
- genome wide
- young adults
- multidrug resistant
- deep learning
- hepatitis c virus
- human immunodeficiency virus
- antiretroviral therapy
- simultaneous determination
- contrast enhanced ultrasound