Immunosuppressive Drug-Resistant Armored T-Cell Receptor T Cells for Immune Therapy of HCC in Liver Transplant Patients.

Morteza HafeziMeiyin LinAdeline ChiaAlicia ChuaZi Zong HoRoyce FamDamien TanJoey AwAndrea PavesiThinesh Lee KrishnamoorthyWan Cheng ChowWenjie ChenQi ZhangLu-En WaiSarene KohAnthony T TanAntonio Bertoletti

Published in: Hepatology (Baltimore, Md.) (2021)

We engineered TCR-T cells of desired specificities that transiently escape the immunosuppressive effects of TAC and MMF. This finding has important clinical applications for the treatment of HBV-HCC relapses and other pathologies occurring in organ transplanted patients.

Keyphrases

drug resistant
end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
multidrug resistant
prognostic factors
peritoneal dialysis
stem cells
acinetobacter baumannii
bone marrow
mesenchymal stem cells
cystic fibrosis
pseudomonas aeruginosa
regulatory t cells
patient reported