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Strategies for the development of metalloimmunotherapies.

Xiaoqi SunXingwu ZhouXiaoyue ShiOmar A AbedXinran AnYu Leo LeiJames J Moon
Published in: Nature biomedical engineering (2024)
Metal ions play crucial roles in the regulation of immune pathways. In fact, metallodrugs have a long record of accomplishment as effective treatments for a wide range of diseases. Here we argue that the modulation of interactions of metal ions with molecules and cells involved in the immune system forms the basis of a new class of immunotherapies. By examining how metal ions modulate the innate and adaptive immune systems, as well as host-microbiota interactions, we discuss strategies for the development of such metalloimmunotherapies for the treatment of cancer and other immune-related diseases.
Keyphrases
  • quantum dots
  • immune response
  • induced apoptosis
  • aqueous solution
  • papillary thyroid
  • water soluble
  • cell cycle arrest
  • squamous cell carcinoma
  • squamous cell
  • young adults