Login / Signup

Black mulberry fruit extract alleviates streptozotocin-induced diabetic nephropathy in rats: targeting TNF-α inflammatory pathway.

Tarek Kamal AbouzedKadry M SadekEmad Waded GhazyWalied AbdoMohmed Atef KassabSalma HagoSamia Abdel-WahabEngy A MahrousEssam A Abdel-SattarDoaa H Assar
Published in: The Journal of pharmacy and pharmacology (2020)
The ameliorative effect of BMFE on diabetic nephropathy is not only through its potent antioxidant and hypoglycaemic effects but also through its downregulation of TNF-α, VCAM-1 and fibronectin mRNA expression in renal tissues of diabetic-treated rats. Therefore, BMFE as dietary supplement could be a promising agent in improving diabetic nephropathy.
Keyphrases
  • diabetic nephropathy
  • oxidative stress
  • diabetic rats
  • rheumatoid arthritis
  • anti inflammatory
  • type diabetes
  • gene expression
  • high glucose
  • cell proliferation
  • drug delivery
  • newly diagnosed
  • type iii
  • skeletal muscle