CIRKIL Exacerbates Cardiac Ischemia/Reperfusion Injury by Interacting With Ku70.

Hongwen XiaoMingyu ZhangHao WuJiaxu WuXiaoxi HuXinyu PeiDanyang LiLu ZhaoQi HuaBo MengXiaowen ZhangLili PengXiaoling ChengZhuoyun LiWanqi YangQi ZhangYang ZhangYanjie LuZhen-Wei Pan

Published in: Circulation research (2022)

CIRKIL is a detrimental factor in I/R injury acting via regulating nuclear translocation of Ku70 and DNA double-strand breaks repair. Thus, CIRKIL might be considered as a novel molecular target for the treatment of cardiac conditions associated with I/R injury.

Keyphrases

left ventricular
single molecule
circulating tumor
cell free
combination therapy
protein kinase
replacement therapy
circulating tumor cells