Metabolomic changes in Mycobacterium avium subsp. paratuberculosis (MAP) challenged Holstein-Friesian cattle highlight the role of serum amino acids as indicators of immune system activation.
Emma N TaylorManfred BeckmannBryan K MarkeyStephen Vincent GordonR Glyn HewinsonDavid RookeLuis Alejandro Jose MurPublished in: Metabolomics : Official journal of the Metabolomic Society (2022)
The targeted metabolites suggest shifts in amino acid metabolism that could reflect immune system activation linked to MAP and as well as differences in phosphocholine levels which could reflect activation of the Th1 (tending towards pro-inflammatory) immune response. If verified by future work, selected metabolites could be used as biomarkers to diagnose and manage MAP infected cattle.