Protective Effect of Two Alkaloids from Hippophae rhamnoides Linn. against Doxorubicin-Induced Toxicity in H9c2 Cardiomyoblasts.
Wenna ZhouJian OuyangNa HuGang LiHonglun WangPublished in: Molecules (Basel, Switzerland) (2021)
These results suggest that alk-A and alk-B can inhibit Dox-induced apoptosis in H9C2 cardiac muscle cells via inhibition of cell apoptosis and improvement of mitochondrial function, while alk-B showed more protection. Alk-B could be a potential candidate agent for protecting against cardiotoxicity in Dox-exposed patients.
Keyphrases
- induced apoptosis
- endoplasmic reticulum stress
- oxidative stress
- advanced non small cell lung cancer
- signaling pathway
- end stage renal disease
- diabetic rats
- newly diagnosed
- ejection fraction
- chronic kidney disease
- skeletal muscle
- high glucose
- cell proliferation
- patient reported outcomes
- heart failure
- left ventricular
- cell cycle arrest
- risk assessment
- endothelial cells
- pi k akt