Six-minute walk test as outcome measure of fatigability in adults with spinal muscular atrophy treated with nusinersen.
Alessandra GovoniGiulia RicciSilvia BonannoLuca BelloFrancesca MagriMegi MeneriFrancesca TorriClaudia CaponnettoLuigia PassamanoMarina GrandisFrancesca TrojsiFederica CerriGiulio GadaletaGiuliana CapeceLuca CaumoRaffaella TanelElena SaccaniVeria VacchianoGianni SorarùEustachio D'ErricoIrene TramacereSara BortolaniEnrica RolleCinzia GelleraRiccardo ZaninMauro SilvestriniLuisa PolitanoAngelo SchenoneStefano Carlo PrevitaliAngela BerardinelliMara TurriLorenzo VerrielloMichela CocciaRenato MantegazzaRocco LiguoriMassimiliano FilostoMaria Antonietta MaioliIsabella Laura SimoneTiziana MonginiStefania CortiMaria Laura MancaElena PegoraroGabriele SicilianoGiacomo Pietro ComiLorenzo MaggiPublished in: Muscle & nerve (2024)
Fatigability was detected at baseline in approximately 2/3 of SMA3 walker patients, without any correlation with clinical features, included motor performance. No effect on fatigability was observed during the 14-month treatment period with nusinersen.