Structure-Element Surface Modification Strategy Enhances the Antibacterial Performance of Zr-BMGs.

Zirconium-based metallic glasses (Zr-BMGs) have attracted tremendous attention in healthcare fields, especially in the design of surgical tools and orthopedic implants, due to their unique amorphous structure; however, the application of Zr-BMG-based medical devices is hindered by bacterial contamination. Here, a structure-element strategy is proposed to improve the antibacterial performance of Zr-BMGs by surface laser nanostructuring and silver nanoparticle (AgNP) deposition. The laser nanostructuring process generates a disordered nanoparticle structure (NP) and laser-induced periodic surface structure (LIPSS) to decrease the surface bacterial adhesion and increase the internal antimicrobial ion release. Moreover, after Ag deposition and hydrogen peroxide (H 2 O 2 ) treatment, the antibacterial adhesion ability of the Zr-BMG surface can be further improved without any influence on the crystallization of Zr-BMGs and the release of antibacterial copper/nickel (Cu/Ni). The antibacterial effect of the LIPSS and the NP surfaces presents over 90% bacterial killing ratio, which is superior to that of the naked Zr-BMGs with less than 60% bacterial killing ratio. In vitro and in vivo tests show that the Ag-deposited and H 2 O 2 -treated LIPSS surfaces exhibit an optimal balance between the antibacterial property and the biocompatibility compared with the polished, NP structured or LIPSS structured surfaces. It is assumed that such structure-element surface modification strategy can improve the antibacterial activity of metal-containing surgical tools and orthopedic implants, improving the success rate of medical treatment.