Suramin prevents the development of diabetic kidney disease by inhibiting NLRP3 inflammasome activation in KK-Ay mice.

Kaori OdaSatoshi MiyamotoRyo KoderaJun Wada Kenichi Shikata

Published in: Journal of diabetes investigation (2022)

These results suggest that the NLRP3 inflammasome is activated in a diabetic kidney and that inhibition of the NLRP3 inflammasome with suramin protects against the progression of early stage DKD.

Keyphrases

nlrp inflammasome
early stage
type diabetes
wound healing
signaling pathway
high fat diet induced
mouse model
sentinel lymph node
adipose tissue
skeletal muscle
insulin resistance
neoadjuvant chemotherapy