Inherited Germline Cancer Susceptibility Gene Variants in Individuals with Non-Muscle-Invasive Bladder Cancer.

Eugene J Pietzak Karissa A Whiting Preethi Srinivasan Chaitanya BandlamudiAliya KhurramJoseph VijaiAleksandra WalasekEmily BochnerTimothy N Clinton Nima Almassi Hong Truong Manuel R de Jesus Escano Michal Wiseman Diana L Mandelker Yelena M Kemel Zarina Yelskaya Michael F WalshKaren A CadooJonathan A Coleman Hikmat A Al-Ahmadie Jonathan E RosenbergGopakumar V IyerDavid B Solit Irina Ostrovnaya Kenneth Offit Mark E Robson Zsofia K Stadler Michael F Berger Dean F Bajorin Maria Isabel CarloBernard H Bochner

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

Our results support offering germline counseling and testing for all patients with high-grade bladder cancer, regardless of initial tumor stage. Therapeutic strategies that target impaired DNA repair may benefit patients with high-grade NMIBC.

Keyphrases

dna repair
high grade
muscle invasive bladder cancer
low grade
dna damage
copy number
papillary thyroid
dna damage response
squamous cell
genome wide
smoking cessation
oxidative stress
gene expression
hiv testing
squamous cell carcinoma
lymph node metastasis
young adults
genome wide analysis