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Single-Cell RNA Sequencing Identifies Response of Renal Lymphatic Endothelial Cells to Acute Kidney Injury.

Heidi A CreedSaranya KannanBrittany L TateDavid GodefroyPriyanka BanerjeeBrett M MitchellEbba BrakenhielmSanjukta ChakrabortyJoseph M Rutkowski
Published in: Journal of the American Society of Nephrology : JASN (2024)
In this study, we uncover lymphatic vessel structural features of captured populations and injury-induced genetic changes. We further determine that lymphatic endothelial cell gene expression is altered between injury models. How lymphatic endothelial cells respond to AKI may therefore be key in regulating future kidney disease progression.
Keyphrases
  • endothelial cells
  • high glucose
  • lymph node
  • single cell
  • gene expression
  • genome wide
  • rna seq
  • acute kidney injury
  • vascular endothelial growth factor
  • copy number
  • genetic diversity