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Nickel-Catalyzed Direct Cross-Coupling of Unactivated Aryl Fluorides with Aryl Bromides.

Jing-Ao RenJin-He NaChao GuiChengping MiaoXue-Qiang ChuMengtao MaHao XuXiaocong ZhouZhi-Liang Shen
Published in: Organic letters (2023)
A nickel-catalyzed direct cross-coupling of unactivated aryl fluorides with aryl bromides is realized. The one-pot reaction, which avoids the use of preformed and sensitive organometallic reagents, proceeds effectively via C-F bond cleavage at room temperature in THF in the presence of the phosphine ligand and magnesium powder (with or without TMSCl) to produce the desired biaryls in modest to good yields.
Keyphrases
  • room temperature
  • ionic liquid
  • reduced graphene oxide
  • transcription factor
  • electron transfer