HLA-DQ Mismatches Lead to More Unacceptable Antigens, Greater Sensitization, and Increased Disparities in Repeat Transplant Candidates.
Dylan IsaacsonJesse D ScholdMichael W GmeinerHannah C CopleyVasilis KosmoliaptsisAnat Roitberg TamburPublished in: Journal of the American Society of Nephrology : JASN (2022)
HLA-DQ mismatches had the strongest associations with UA-PD, an effect that was greatest in African American and Hispanic recipients. cPRA increases with HLA-DQ UA-PD were equivalent or larger than any other HLA locus. This suggests a need to consider the effects of HLA-DQ in kidney allocation.