Profiling of unfolded protein response markers and effect of IRE1α-specific inhibitor in pituitary neuroendocrine tumor.

Shuhei Morita Shinsuke UrakiHiroyuki AriyasuTomoya TsujiAsako DoiHiroto FurutaToshikazu YamotoNaoyuki NakaoTakashi AkamizuTaka-Aki Matsuoka

Published in: Endocrinology (2024)

UPR markers in FPitNETs are implicated as dominant A-UPR but blunted T-UPR. KIRA8, enhanced with octreotide, unbalances UPR, leading to anti-tumor effects. Targeting IRE1α may provide a novel strategy to treat PitNETs.

Keyphrases

endoplasmic reticulum stress
single cell
drug delivery
binding protein
neuroendocrine tumors
endoplasmic reticulum