Application of Extracellular Vesicles in Allergic Rhinitis: A Systematic Review.
Katarzyna CzerwatyKarolina DzamanWiktor MiechowskiPublished in: International journal of molecular sciences (2022)
The pathophysiology of allergic rhinitis (AR), one of the most common diseases in the world, is still not sufficiently understood. Extracellular vesicles (EVs), which are secreted by host and bacteria cells and take part in near and distant intracellular communication, can provide information about AR. Recently, attention has been drawn to the potential use of EVs as biomarkers, vaccines, or transporters for drug delivery. In this review, we present an up-to-date literature overview on EVs in AR to reveal their potential clinical significance in this condition. A comprehensive and systematic literature search was conducted following PRISMA statement guidelines for original, completed articles, available in English concerning EVs and AR. For this purpose, PubMed/MEDLINE, Scopus, Web of Science, and Cochrane, were searched up until 10 Novenmber 2022. From 275 records, 18 articles were included for analysis. The risk of bias was assessed for all studies as low or moderate risk of overall bias using the Office and Health Assessment and Translation Risk of Bias Rating Tool for Human and Animal Studies. We presented the role of exosomes in the pathophysiology of AR and highlighted the possibility of using exosomes as biomarkers and treatment in this disease.
Keyphrases
- allergic rhinitis
- drug delivery
- public health
- systematic review
- mesenchymal stem cells
- stem cells
- healthcare
- endothelial cells
- induced apoptosis
- mental health
- human health
- health information
- working memory
- gene expression
- cancer therapy
- endoplasmic reticulum stress
- oxidative stress
- social media
- cell proliferation
- signaling pathway
- reactive oxygen species
- climate change
- cell death
- combination therapy
- health promotion
- meta analyses
- replacement therapy
- pi k akt