Phase Ib Study of Chemoprevention with Green Tea Polyphenon E and Erlotinib in Patients with Advanced Premalignant Lesions (APL) of the Head and Neck.
Dong M ShinSreenivas NannapaneniMihir R PatelQiuying ShiYuan LiuZhengjia ChenAmy Y ChenMark W El-DeiryJonathan J BeitlerConor E SteuerSteven M RoserAdam M KleinTaofeek Kunle OwonikokoSuresh S RamalingamFadlo R KhuriZhuo G ChenNabil F SabaPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
Treatment with PPE and erlotinib combination was well tolerated in patients with APLs of the head and neck, and showed a high rate of pathologic response with excellent CFS. This combination deserves further investigation for the chemoprevention and/or prevention of second primary tumors in early-stage head and neck cancer.