Evidence Supporting the Safety of Pegylated Diethylaminoethyl-Chitosan Polymer as a Nanovector for Gene Therapy Applications.
Elsa Patricia RondonHouda Abir BenabdounFrancis VallièresMaicon Segalla PetrônioMarcio José TieraMohamed BenderdourJulio Cesar FernandesPublished in: International journal of nanomedicine (2020)
These DEAE12-CH-PEG-FA2/siRNA nanoparticles fulfill the existing ISO, ASTM and NCL guidelines' threshold criteria, and their low toxicity and blood biocompatibility warrant further investigation for potential clinical applications.