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Red Blood Cells Homeostatically Bind Mitochondrial DNA through TLR9 to Maintain Quiescence and to Prevent Lung Injury.

Meghan J HotzDanielle QingMichael G S ShashatyPeggy ZhangHilary FaustNeal SondheimerStefano RivellaG Scott WorthenNilam S Mangalmurti
Published in: American journal of respiratory and critical care medicine (2019)
RBCs homeostatically bind mtDNA, and RBC-mediated DNA scavenging is essential in mitigating lung injury after CpG-DNA. Our data suggest a role for RBCs in regulating lung inflammation during disease states where cf-mtDNA is elevated, such as sepsis and trauma.
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