Red Blood Cells Homeostatically Bind Mitochondrial DNA through TLR9 to Maintain Quiescence and to Prevent Lung Injury.
Meghan J HotzDanielle QingMichael G S ShashatyPeggy ZhangHilary FaustNeal SondheimerStefano RivellaG Scott WorthenNilam S MangalmurtiPublished in: American journal of respiratory and critical care medicine (2019)
RBCs homeostatically bind mtDNA, and RBC-mediated DNA scavenging is essential in mitigating lung injury after CpG-DNA. Our data suggest a role for RBCs in regulating lung inflammation during disease states where cf-mtDNA is elevated, such as sepsis and trauma.
Keyphrases
- mitochondrial dna
- red blood cell
- copy number
- circulating tumor
- cell free
- single molecule
- dna methylation
- oxidative stress
- cystic fibrosis
- intensive care unit
- toll like receptor
- genome wide
- acute kidney injury
- inflammatory response
- immune response
- nucleic acid
- septic shock
- trauma patients
- gene expression
- machine learning