Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain.
Aimée ParkerStefano RomanoRebecca AnsorgeAsmaa AboelnourGwenaelle Le GallGeorge M SavvaMatthew G PontifexAndrea TelatinDavid BakerEmily JonesDavid VauzourSteven RudderL Ashley BlackshawGlen JefferySimon R CardingPublished in: Microbiome (2022)
These findings demonstrate that the aging gut microbiota drives detrimental changes in the gut-brain and gut-retina axes suggesting that microbial modulation may be of therapeutic benefit in preventing inflammation-related tissue decline in later life. Video abstract.