PET Detection of Cerebral Necrosis Using an Infarct-Avid Agent 2-Deoxy-2-[18F]Fluoro-D-Glucaric Acid (FGA) in a Mouse Model of the Brain Stroke.
Hailey HousonAlexander MdzinarishviliHariprasad GaliEvgeny SidorovVibhudutta AwasthiPublished in: Molecular imaging and biology (2021)
Accumulation of FGA correlated well with the perfusion defect and inflammatory injury. As a PET agent, FGA has potential to image infarcted core in the brain stroke injury with high sensitivity, resolution, and specificity.
Keyphrases
- cerebral ischemia
- positron emission tomography
- mouse model
- atrial fibrillation
- computed tomography
- resting state
- subarachnoid hemorrhage
- white matter
- pet ct
- functional connectivity
- pet imaging
- brain injury
- blood brain barrier
- oxidative stress
- acute myocardial infarction
- heart failure
- loop mediated isothermal amplification
- single molecule
- contrast enhanced
- machine learning
- human health
- magnetic resonance
- climate change
- quantum dots