Clinico-pathological and molecular characterization of diffuse midline gliomas: is there a prognostic significance?
Niveditha ManjunathPrerana JhaJyotsna SinghAmol RahejaKavneet KaurAshish SuriAjay GargMehar Chand SharmaChitra SarkarMadan MohanKalaivani ManiVaishali SuriPublished in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2020)
The study highlights the differences in frequency and location of pediatric and adult DMGs. IHC (H-scoring) for H3K27M mutation is an excellent surrogate for sequencing. Prognosis remains dismal irrespective of age, location, and H3K27M status. Potential therapeutic targets need to be explored.
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