Preoperative factors that predict pathologic nodal involvement in early-stage HER2+ breast cancer: selecting cT1cN0 patients for treatment with neoadjuvant chemotherapy versus upfront surgery.
Sohayb FalehIpshita PrakashAida SalehiHaseeb KhanMark BasikJean Francois BoileauDavid TejeraFrancois PanetKaryne MartelSarkis MeterissianStephanie M WongPublished in: Breast cancer research and treatment (2024)
Patients with cT1cN0 breast cancer have a 32.5% likelihood of nodal metastases, with higher incidence with younger age, LVI, multifocality/multicentricity, and abnormal axillary ultrasound. The presence of these factors may identify the patients who would benefit from treatment with neoadjuvant chemotherapy.
Keyphrases
- neoadjuvant chemotherapy
- sentinel lymph node
- lymph node
- locally advanced
- early stage
- end stage renal disease
- magnetic resonance imaging
- computed tomography
- rectal cancer
- ejection fraction
- chronic kidney disease
- newly diagnosed
- contrast enhanced
- lymph node metastasis
- patients undergoing
- dual energy
- prognostic factors
- risk factors
- radiation therapy
- positron emission tomography
- coronary artery bypass