The Correlation Between the Autotaxin Enzyme and Pruritus in Egyptian Patients Suffering from Chronic Liver Disease.

Fathia AsalDina ZiadaAyman WagehMohammed El-KohyNehad HawashSherief Abd-ElsalamRehab Badawi

Published in: Anti-inflammatory & anti-allergy agents in medicinal chemistry (2022)

Serum autotaxin level was elevated in patients with chronic liver diseases with pruritus. Autotaxin enzyme may play a key role in the induction of hepatogenic pruritus. So, autotaxin enzyme inhibitors and lysophosphatidic acid (LPA) receptor blockers could be a future line of treatment of hepatogenic pruritus.

Keyphrases

atopic dermatitis
end stage renal disease
ejection fraction
newly diagnosed
prognostic factors
current status
angiotensin converting enzyme
replacement therapy
angiotensin ii
smoking cessation
binding protein