Strategies to identify causal common genetic variants and corresponding effector genes for paediatric obesity.
Sheridan H LittletonStruan F A GrantPublished in: Pediatric obesity (2022)
Uncovering the causative genes related to GWAS signals and elucidating their functional contributions to paediatric obesity with these strategies will deepen our understanding of this disease and serve better treatment outcomes.
Keyphrases
- insulin resistance
- metabolic syndrome
- weight loss
- intensive care unit
- high fat diet induced
- genome wide
- type diabetes
- emergency department
- weight gain
- bioinformatics analysis
- genome wide identification
- regulatory t cells
- dendritic cells
- adipose tissue
- dna methylation
- body mass index
- genome wide analysis
- transcription factor
- skeletal muscle
- type iii