Within-host rhinovirus evolution in upper and lower respiratory tract highlights capsid variability and mutation-independent compartmentalization.

Negar MakhsousStephanie Goya Carlos AvendañoJason RuppJane KuypersKeith R Jerome Michael J Boeckh Alpana Waghmare Alexander L Greninger

Published in: bioRxiv : the preprint server for biology (2023)

HRV infections in immunocompromised hosts can progress from URT to LRT with no specific evolutionary requirement. Capsid proteins carry the highest variability and emergent mutations can be detected in other, including future, HRV sequences.

Keyphrases

respiratory tract
current status
genome wide
intensive care unit
mechanical ventilation