Activation of succinate receptor 1 boosts human mast cell reactivity and allergic bronchoconstriction.
Xiao TangElin RönnbergJesper SäfholmMadhuranayaki ThulasingamMette TrauelsenThue W SchwartzCraig E WheelockSven-Erik DahlénGunnar P NilssonJesper Z HaeggströmPublished in: Allergy (2022)
SUCNR1 amplifies IgE-receptor-induced mast cell activation and allergic bronchoconstriction, suggesting a role for this pathway in aggravation of allergic asthma, thus linking metabolic perturbations to mast cell-dependent inflammation.