Stereodefined synthesis of cyclic amidines by domino 1,7-H shift and 6π electrocyclisation.
Matthew L MartinClaire WilsonAlistair BoyerPublished in: Chemical communications (Cambridge, England) (2023)
Unsaturated N 2 -sulfonyl amidines are transformed into valuable N-heterocyclic products when heated with BF 2 OTf. Mechanism studies suggest a domino 1,7-H shift, activating a C-H bond, followed by electrocylisation that results in stereodefined cyclic amidines.
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