Targeted ablation of the cellular inhibitor of apoptosis 1 (cIAP1) attenuates denervation-induced skeletal muscle atrophy.
Neena Lala-TabbertRim Lejmi-MradKristen TimuskMarina FukanoJanelle HolbrookMartine St-JeanEric C LaCasseRobert G KornelukPublished in: Skeletal muscle (2019)
These results demonstrate the cIAP1 is an important mediator of NF-κB/MuRF1 signaling in skeletal muscle atrophy and is a promising therapeutic target for muscle wasting diseases.
Keyphrases
- skeletal muscle
- oxidative stress
- insulin resistance
- diabetic rats
- signaling pathway
- high glucose
- endoplasmic reticulum stress
- cell cycle arrest
- lps induced
- cell death
- pi k akt
- cancer therapy
- drug induced
- nuclear factor
- type diabetes
- radiofrequency ablation
- inflammatory response
- adipose tissue
- metabolic syndrome
- toll like receptor
- catheter ablation
- atrial fibrillation