Hidden dissemination of carbapenem-susceptible OXA-48-producing Proteus mirabilis.

Rosa PedrazaNicolas KiefferJulia Guzmán-PucheMaría José ArtachoCristina PitartMarta Hernandez-GarcíaJordi VilaRafael CantónLuis Martinez-Martinez

Published in: The Journal of antimicrobial chemotherapy (2022)

The presence of a chromosomal copy of blaOXA-48 did not confer resistance to carbapenems, but a single mutation in the promoter could lead to an increase in resistance. This study shows a hidden circulation of OXA-48-positive, but carbapenem- and piperacillin/tazobactam-susceptible, P. mirabilis isolates that can become resistant to β-lactams after a single mutation.

Keyphrases

acinetobacter baumannii
klebsiella pneumoniae
multidrug resistant
drug resistant
pseudomonas aeruginosa
gram negative
escherichia coli
dna methylation
gene expression
genome wide