Prognostic role of detailed colorectal location and tumor molecular features: analyses of 13,101 colorectal cancer patients including 2994 early-onset cases.
Tomotaka UgaiNaohiko AkimotoKoichiro HarukiTabitha A HarrisonYin CaoConghui QuAndrew T ChanPeter T CampbellSonja I BerndtDaniel D BuchananAmanda J CrossBrenda DiergaardeSteven J GallingerMarc J GunterSophia HarlidAkihisa HidakaMichael HoffmeisterHermann BrennerJenny Chang-ClaudeLi HsuMark A JenkinsYi LinRoger L MilneVictor MorenoPolly A NewcombReiko NishiharaMireia Obon-SantacanaRish K PaiLori C SakodaRobert E SchoenMartha L SlatteryWei SunEfrat L AmitayElizabeth AlwersStephen N ThibodeauAmanda E TolandBethany Van GuelpenSyed H ZaidiJohn D PotterJeffrey A MeyerhardtMarios GiannakisMingyang SongJonathan A NowakUlrike PetersAmanda I PhippsShuji OginoPublished in: Journal of gastroenterology (2023)
Both detailed colonic location and tumor molecular features need to be accounted for colon cancer prognostication to advance precision medicine. Our study indicates the important role of large-scale studies to robustly examine detailed colonic subsites in molecular oncology research.