Delivery of Helicobacter pylori HpaA to gastrointestinal mucosal immune sites using Lactococcus lactis and its immune efficacy in mice.

Rongguang ZhangChen WangWenbin ChengRongguang ZhangQingfeng ShiShuaiyin ChenQingtang Fan

Published in: Biotechnology letters (2018)

A novel engineered L. lactis strain was developed that efficiently produces whole HpaA protein with desired antigenicity and potent immunogenicity. It provides a basis for approaches to L. lactis-delivered anti-H. pylori vaccination.

Keyphrases

helicobacter pylori
helicobacter pylori infection
high fat diet induced
protein protein
type diabetes
binding protein
anti inflammatory
small molecule
wild type