Pigs immunized with a novel E2 subunit vaccine are protected from subgenotype heterologous classical swine fever virus challenge.
Rachel MaderaWenjie GongLihua WangYulia BurakovaKaren LleellishAmy Galliher-BeckleyJerome NietfeldJamie HenningsonKaimin JiaPing LiJianfa BaiJohn SchlupScott McVeyChangchun TuJishu ShiPublished in: BMC veterinary research (2016)
Our studies provide direct evidence that pigs immunized with one dose KNB-E2 can be protected clinically from CSFV challenge. This protection is likely mediated by high levels of E2-specific and anti-CSFV neutralizing antibodies.