NG2-positive pericytes regulate homeostatic maintenance of slow-type skeletal muscle with rapid myonuclear turnover.
Takamitsu TatsukawaKohei KanoKei-Ichi NakajimaTakashi YazawaRyoji EguchiMaki KabaraKiwamu HoriuchiTaiki HayasakaRisa MatsuoNaoyuki HasebeNobuyoshi AzumaJun-Ichi KawabePublished in: Stem cell research & therapy (2023)
These findings demonstrate that the turnover of myonuclei in slow-type myofibers is relatively fast, with PCs acting as myogenic stem cells-the suppliers of new myonuclei under steady conditions-and play a vital role in the homeostatic maintenance of slow-type muscles.